Hydrochloric Acid → Methyl(2-phenylethyl)amine hydrochloride
反応式
[CH2:1](Br)C#C.C[CH:6]([NH2:14])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[ClH:15].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[ClH:15].[CH3:1][NH:14][CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1参加物
6
実験手順
A solution of propargyl bromide (1.1 g, 9.1 mmol) in acetonitrile (8.5 ml) was added dropwise to a stirred mixture of 3-(N-Me, N-Et carbamyloxy)α-methyl phenethylamine.HCl (2.4 g, 8.8 mmol) and potassium carbonate (2.8 g) in acetonitrile (25 ml), and the mixture was stirred at RT for 7 hrs. The reaction mixture was filtered and the filtrate was removed under reduced pressure and the residue was purified by column chromatography (hexane:EtOAc 2:1) to give 1.76 g of the title compound as the free base (73%)
後処理
- filtrationThe reaction mixture was filtered
- customthe filtrate was removed under reduced pressure
- customthe residue was purified by column chromatography (hexane:EtOAc 2:1)
出典と根拠
- ORDレコード
- ord-e0209af03ab948a7b6533ff083cb6f04
- 出典データセット
- uspto-grants-2001_06
- 特許番号
- US06251938B1
反応ノート
読み込み中…