4-Nitro-L-phenylalanine methyl ester → 4-Amino-L-phenylalanine methyl ester

HRID 1069156ノート

反応式

HRID 1069156 の反応式
[CH3:1][O:2][C:3](=[O:16])[C@H:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=1)[NH2:5]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:16])[C@H:4]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([NH2:13])=[CH:11][CH:12]=1)[NH2:5]

参加物

4

反応物 1

HCID 74082814-Nitro-L-phenylalanine methyl ester

生成物 1

HCID 206108304-Amino-L-phenylalanine methyl ester収率 102.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To the product from Step A (5.08 g) in MeOH (75 mL) was added 10% Pd/C (900 mg) in a Parr bottle. This was then shaken on a Parr shaker under 50 psi H2 at room temperature for 4.5 hours. The catalyst was filtered through celite, the solvent removed under vacuum and the crude product purified by reverse phase preparatory HPLC to yield 4.5 g of p-amino-phenylalanine methyl ester, N-isobutyl carbamate, trifluoroacetate as a hygroscopic yellow solid.

後処理

  1. filtrationThe catalyst was filtered through celite
  2. customthe solvent removed under vacuum
  3. customthe crude product purified by reverse phase preparatory HPLC

出典と根拠

ORDレコード
ord-022c6d61753e4bd88f03464e42a5aa91
出典データセット
uspto-grants-2001_06
特許番号
US06251944B1

反応ノート

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