Trifluoroacetic acid → (4-Benzyloxy-phenyl)-(3-methyl-but-2-enyl)-[1-(3-methyl-butyl)-piperidin-4-yl]-amine

The preparation of (4-Benzyloxy-phenyl)-(3-methvl-but-2-enyl)-piperidin-4-yl-amine, (Ic): 4-[(4-Benzyloxy-phenyl)-(3-methyl-but-2-enyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (5.0 g, 11.1 mmol) was dissolved in CH2Cl2 (20 mL) and treated with TFA (20 mL). The reaction was stirred for ten minutes, then concentrated in vacuo. The residue was redissolved in EtOAc (400 mL), then washed with saturated bicarbonate solution (2×400 mL) and brine (1×400 mL), dried over Na2SO4, and concentrated in vacuo to give 3.9 g (99%) of the desired product as a pale oil.

1. concentrationconcentrated in vacuo
2. dissolutionThe residue was redissolved in EtOAc (400 mL)
3. washwashed with saturated bicarbonate solution (2×400 mL) and brine (1×400 mL)
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo

ORDレコード

ord-7bb534feb1114cb7b0a982a6780646b2

出典データセット

uspto-grants-2001_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06251919B1