HCID 10947021、化合物 → Methyl 3-Amino-6-methyl-2-oxo-4-(phenylmethyl)-1,2-dihydropyridine-1-acetate

HRID 1069427ノート

反応式

HRID 1069427 の反応式
[CH3:1][C:2]1[N:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:13])[C:5]([N+:14]([O-])=O)=[C:4]([CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:3]=1>[Pd].CO>[NH2:14][C:5]1[C:6](=[O:13])[N:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[C:2]([CH3:1])=[CH:3][C:4]=1[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

4

反応物 1

HCID 10947021HCID 10947021、化合物

生成物 1

HCID 15858475Methyl 3-Amino-6-methyl-2-oxo-4-(phenylmethyl)-1,2-dihydropyridine-1-acetate

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

10 g (31.6 mmol) of methyl 6-methyl-3-nitro-2-oxo-4-(phenylmethyl)-1,2-dihydropyridine-1-acetate are placed in a Parr flask and 150 ml of methanol are added. 1 g of 10% palladium on carbon is then introduced and the mixture is hydrogenated at 0.28 MPa (40 psi) at room temperature for 2 hours. The mixture is filtered on celite and the solvent is evaporated to dryness.

後処理

  1. additionare added
  2. filtrationThe mixture is filtered on celite
  3. customthe solvent is evaporated to dryness

出典と根拠

ORDレコード
ord-63e60186346240ee9068c206224d44b2
出典データセット
uspto-grants-2001_06
特許番号
US06252082B1

反応ノート

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