1-Iodooctane → HCID 53772942、化合物

HRID 1069599

反応式

HRID 1069599 の反応式
[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[NH:8][C:7]=1[CH3:17])[CH3:2].[H-].[Na+].I[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]>>[CH2:1]([O:3][C:4](=[O:18])[CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[N:8]([CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[C:7]=1[CH3:17])[CH3:2]

参加物

4

反応物 3

HCID 123801-IodooctaneHCID 24758Sodium hydrideHCID 10729163Ethyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate

生成物 1

HCID 53772942HCID 53772942、化合物収率 51.5%

実験手順

Using the procedure described in Example 50, Part A, 2.47 g (0.01 mol) of 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester was reacted with 0.48 g (0.012 mol) of 60% NaH/mineral oil and then 2.17 mL (0.012 mol of iodooctane. The product was chromatographed on silica gel and eluted with 5% EtOAc/toluene to give 1.85 g (51% yield) of 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester as an oil.

後処理

  1. customThe product was chromatographed on silica gel
  2. washeluted with 5% EtOAc/toluene

出典と根拠

ORDレコード
ord-a0b2dd99105f4b3f893c474cfc89ab4b
出典データセット
uspto-grants-2001_06
特許番号
US06252084B1

関連ノート

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