Trichloroisocyanuric Acid → Methyl 2-(chloromethyl)pyridine-3-carboxylate

HRID 1070430ノート

反応式

HRID 1070430 の反応式
[CH3:1][C:2]1[N:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[Cl:12]N1C(=O)N(Cl)C(=O)N(Cl)C1=O>ClCCl>[CH3:7][O:6][C:4]([C:3]1[C:2]([CH2:1][Cl:12])=[N:11][CH:10]=[CH:9][CH:8]=1)=[O:5]

参加物

4

反応物 2

HCID 6909Trichloroisocyanuric AcidHCID 7015327Methyl 2-methylnicotinate

生成物 1

HCID 19081344Methyl 2-(chloromethyl)pyridine-3-carboxylate収率 45.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of methyl 2-methylnicotinate (20.0 g, 0.132 mol) and trichloroisocyanuric acid (46.0 g, 0.198 mol) in dichloromethane (100 mL) was stirred at room temperature overnight. The reaction mixture was then washed with saturated aqueous sodium carbonate and saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered, and the solvent evaporated in vacuo to provide the title compound as a yellow liquid (11.2 g), which is used as such in the next step.

後処理

  1. washThe reaction mixture was then washed with saturated aqueous sodium carbonate and saturated aqueous sodium chloride
  2. dry with materialdried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. customthe solvent evaporated in vacuo

出典と根拠

ORDレコード
ord-030aea0f86e740558a593b5da77d0876
出典データセット
uspto-grants-2005_06
特許番号
US06903091B2

反応ノート

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