Lithium Hydroxide → Lithium 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate

HRID 1070498ノート

反応式

HRID 1070498 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13](=[O:20])[CH2:14][CH2:15][C:16]([O:18]C)=[O:17])[CH2:8][CH2:7]1.[OH-].[Li+:26]>CO.O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][C:23]=1[Cl:24])[CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13](=[O:20])[CH2:14][CH2:15][C:16]([O-:18])=[O:17])[CH2:10][CH2:11]1.[Li+:26]

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 22396186Methyl 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate

生成物 1

HCID 23689283Lithium 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate収率 96.2%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

To a solution of methyl 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate (3.72 g) in methanol (30 ml) was added lithium hydroxide (0.41 g) in water (10 ml) which was stirred under nitrogen for 48 hours. The solvent was removed under reduced pressure, the residue was triturated with ether and filtered to leave lithium 4-{[1-(3,4-dichlorobenzyl)-4-piperidinyl]amino}-4-oxobutanoate (3.50 g).

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue was triturated with ether
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-48fcba7667c54c0692e89fad0d5e2871
出典データセット
uspto-grants-2005_06
特許番号
US06903085B1

反応ノート

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