Sodium Hydroxide → 2-(Pyrimidin-2-yloxy)acetic acid

HRID 1070518

反応式

HRID 1070518 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([O:11]CC)=[O:10].[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[O:7][CH2:8][C:9]([OH:11])=[O:10]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 22396258Ethyl 2-pyrimidinyloxyacetate

生成物 1

HCID 5662722-(Pyrimidin-2-yloxy)acetic acid収率 58.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 2-pyrimidinyloxyacetate (1.4 g) was dissolved in ethanol (10 ml). Sodium hydroxide (2M aq) was added and the mixture was stirred for 64 h. The solvent was evaporated and the residue was dissolved in water, filtered and the acidified with concentrated hydrochloric acid. The resulting precipitate was collected and dried to give the subtitle compound (0.698 g).

後処理

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in water
  3. filtrationfiltered
  4. customThe resulting precipitate was collected
  5. customdried

出典と根拠

ORDレコード
ord-fde72d6116224d3081aa845e2d8ee2c7
出典データセット
uspto-grants-2005_06
特許番号
US06903085B1

関連ノート

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