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4-Hydroxymethylpyridine → N-(4-Chlorophenyl)-4-[(pyridin-4-yl)methoxy]phthalazin-1-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxymethylpyridine | HCID 11472 | — |
| 反応物 | 1-Chloro-4-(4-chlorophenylamino)-phthalazine | HCID 12075649 | — |
| 溶媒 | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| 生成物 | N-(4-Chlorophenyl)-4-[(pyridin-4-yl)methoxy]phthalazin-1-amine | HCID 22397275 | 87% |
反応手順
The general procedure used for the preparation of Example 3 was used in step 1 of the preparation of Example 4 from 1-chloro-4-(4-chlorophenylamino)phthalazine and 4-pyridyl-carbinol; (87% yield). TLC (20% acetone/dichloromethane): Rf=0.26.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06903101B1 |
| 出典データセット | uspto-grants-2005_06 |
| ORD ID | ord-b3d2736de81044a7a0a56909c79d6db3 |
| 出典メモ | uspto-grants-2005_06 |