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Formamide → 4-[4-(4-Chlorophenylamino)phthalazin-1-yloxymethyl]pyridin-2-yl carboxylic acid amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formamide | HCID 713 | — |
| 反応物 | N-(4-Chlorophenyl)-4-[(pyridin-4-yl)methoxy]phthalazin-1-amine | HCID 22397275 | — |
| 溶媒 | Dichloromethane acetone triethylamine | HCID 86759755 | — |
| 生成物 | 4-[4-(4-Chlorophenylamino)phthalazin-1-yloxymethyl]pyridin-2-yl carboxylic acid amide | HCID 9909266 | 10% |
反応手順
The general procedure used for the preparation of Example 4 was used to prepare 5 from 1-(4-chlorophenylamino)-4-(4-pyridylmethoxy)phthalazine and formamide; (10% yield). TLC (dichloromethane/acetone/triethylamine 7.5:1.0:0.5): Rf=0.42.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06903101B1 |
| 出典データセット | uspto-grants-2005_06 |
| ORD ID | ord-a5a5bfa4bd224327a6b5303c96444939 |
| 出典メモ | uspto-grants-2005_06 |