HCID 20583266、化合物 → HCID 85803722、化合物

HRID 1070635ノート

反応式

HRID 1070635 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:16]([O-])=O)=[C:6]([S:8]([CH2:11][C:12]([O:14][CH3:15])=[O:13])(=[O:10])=[O:9])[CH:7]=1.[H][H]>CO.[Pd]>[NH2:16][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[CH:7][C:6]=1[S:8]([CH2:11][C:12]([O:14][CH3:15])=[O:13])(=[O:10])=[O:9]

参加物

5

反応物 2

HCID 20583266HCID 20583266、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 85803722HCID 85803722、化合物収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

Palladium (10%) on carbon is added to a solution of methyl ((5-methyl-2-nitro-phenyl)sulfonyl)acetate (Preparation 37, 2.0 g) in MeOH (60 mL) and the solution is shaken on a Parr apparatus under 30 psi of hydrogen. After 3 hours the solution is filtered through Celite and the filter cake eluted with MeOH (60 mL). The combined MeOH eluant is evaporated and the remaining residue placed under high vacuum overnight to obtain 1.76 g (99%) of the title compound as a dark solid. Physical characteristics: MS (ESI+) m/z 244 (M+H).

後処理

  1. filtrationAfter 3 hours the solution is filtered through Celite
  2. washthe filter cake eluted with MeOH (60 mL)
  3. customThe combined MeOH eluant is evaporated
  4. customplaced under high vacuum overnight

出典と根拠

ORDレコード
ord-a931371a1d634e2e8f018cd845ed690d
出典データセット
uspto-grants-2005_06
特許番号
US06903097B2

反応ノート

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