Hydrazine hydrate (1:1) → 2-[2-(4-Diphenylmethyl-piperazin-1-yl)-ethoxy]-ethylamine

反応式

[C:1]1([CH:7]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[N:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][O:16][CH2:17][CH2:18][N:19]3C(=O)C4C(=CC=CC=4)C3=O)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.NN>>[C:30]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][O:16][CH2:17][CH2:18][NH2:19])[CH2:12][CH2:13]2)[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=1

参加物

反応物 2

HCID 24654Hydrazine hydrate (1:1)

HCID 223976762-{2-[2-(4-Diphenylmethyl-piperazinyl)-ethoxy]-ethyl}-isoindol-1,3-dione

生成物 1

HCID 223976322-[2-(4-Diphenylmethyl-piperazin-1-yl)-ethoxy]-ethylamine

実験手順

Batch size: 27 g (55.6 mmol) 2-{2-[2-(4-diphenylmethyl-piperazinyl)-ethoxy]-ethyl}-isoindol-1,3-dione and 5.4 ml (110 mmol) hydrazine-hydrate.

出典と根拠

ORDレコード: ord-e53ba3c9d83346018b29b87789607992
出典データセット: uspto-grants-2005_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06903118B1

反応ノート

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