trans-2-Phenylcyclopropyl isocyanate → N-{4-[4-amino-2-(ethoxymethyl)-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl]butyl}-N'-[(1R*,2S*)-2-phenylcyclopropyl]urea

HRID 1070807

反応式

HRID 1070807 の反応式
[C:1]1([C@@H:7]2[CH2:9][C@H:8]2[N:10]=[C:11]=[O:12])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:13][CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[C:26]2[CH:25]=[C:24]([CH3:27])[N:23]=[C:22]([NH2:28])[C:21]=2[N:20]=[C:19]1[CH2:29][O:30][CH2:31][CH3:32]>>[NH2:28][C:22]1[C:21]2[N:20]=[C:19]([CH2:29][O:30][CH2:31][CH3:32])[N:18]([CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:11]([NH:10][C@@H:8]3[CH2:9][C@H:7]3[C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)=[O:12])[C:26]=2[CH:25]=[C:24]([CH3:27])[N:23]=1

参加物

3

反応物 2

HCID 255285trans-2-Phenylcyclopropyl isocyanateHCID 129729601-(4-aminobutyl)-2-ethoxymethyl-6-methyl-1H-imidazo[4,5-c]pyridin-4-amine

生成物 1

HCID 20575811N-{4-[4-amino-2-(ethoxymethyl)-6-methyl-1H-imidazo[4,5-c]pyridin-1-yl]butyl}-N'-[(1R*,2S*)-2-phenylcyclopropyl]urea

実験手順

Using the method of Examples 36-45, trans-2-phenylcyclopropyl isocyanate was reacted with 1-(4-aminobutyl)-2-ethoxymethyl-6-methyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 437.2666.

出典と根拠

ORDレコード
ord-9177b65a252049ba979555db66bdaeaf
出典データセット
uspto-grants-2005_06
特許番号
US06903113B2

関連ノート

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