Ethanol → 4-(Oxazol-4-yl)aniline

HRID 1070830ノート

反応式

HRID 1070830 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)=[CH:6][CH:5]=1)([O-])=O.C(O)C.[H][H]>[C].[Pd].O1CCCC1>[O:13]1[CH:14]=[C:10]([C:7]2[CH:6]=[CH:5][C:4]([NH2:1])=[CH:9][CH:8]=2)[N:11]=[CH:12]1

参加物

6

反応物 3

HCID 702EthanolHCID 145677974-(4-Nitrophenyl)oxazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 223978534-(Oxazol-4-yl)aniline

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

5% Palladium-carbon powder was added to a suspension of 4-(4-nitrophenyl)-1,3-oxazole in mixture of ethanol and tetrahydrofuran, and the reaction mixture was stirred under 1 atm of hydrogen at ambient temperature for 12 hours. The reaction mixture was filtered through Celite, and the resulting filtrate was concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography, to obtain [4-(1,3-oxazol-4-yl)phenyl]amine (pale yellow solid). Electron Impact-MS (M)+:160.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. concentrationthe resulting filtrate was concentrated under reduced pressure
  3. customThe resulting crude product was purified by silica gel column chromatography

出典と根拠

ORDレコード
ord-95af47684b0e4769aaa2c925c5fec751
出典データセット
uspto-grants-2005_06
特許番号
US06903125B2

反応ノート

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