Methanol → HCID 10237195、化合物

HRID 1070896ノート

反応式

HRID 1070896 の反応式
[N+](=[CH2:3])=[N-].C(OCC)C.[C:9]([C@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:32])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@@H:25]1[C:29]([OH:31])=[O:30])=[O:23])(O)=[O:10].[CH3:33][OH:34]>O1CCCC1>[CH3:33][O:34][C:9]([C@H:12]1[CH2:16][CH2:15][CH2:14][N:13]1[C:17](=[O:32])[CH2:18][CH2:19][CH2:20][CH2:21][C:22]([N:24]1[CH2:28][CH2:27][CH2:26][C@@H:25]1[C:29]([O:31][CH3:3])=[O:30])=[O:23])=[O:10]

参加物

6

反応物 4

HCID 887MethanolHCID 3283Diethyl EtherHCID 9550DiazomethaneHCID 125516Miridesap

生成物 1

HCID 10237195HCID 10237195、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of diazomethane in diethylether (˜6 mmol) was added to a solution of 500 mg (1.5 mmol) (R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid in 10 ml tetrahydrofuran. After stirring overnight methanol was added and the solvents were evaporated. The residue was taken up in dichloromethane, extracted with brine and dried with sodium sulfate. After separation from the solvent 400 mg (72%) (R)-1-{6-[(R) -2-methoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl}-pyrrolidine-2-carboxylic acid methyl ester were obtained as a light yellow oil, MS m/e (%): 369 (M+H+, 100).

後処理

  1. additionwas added
  2. customthe solvents were evaporated
  3. extractionextracted with brine
  4. dry with materialdried with sodium sulfate
  5. customAfter separation from the solvent 400 mg (72%) (R)-1-{6-[(R) -2-methoxycarbonyl-pyrrolidin-1-yl]-6-oxo-hexanoyl}-pyrrolidine-2-carboxylic acid methyl ester
  6. customwere obtained as a light yellow oil, MS m/e (%)

出典と根拠

ORDレコード
ord-41614dc46b954e06ae130b5b54701c64
出典データセット
uspto-grants-2005_06
特許番号
US06903129B2

反応ノート

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