Triphenylphosphane dibromide → 4-Bromo-3-chloro-6,7-dimethoxyquinoline

HRID 1071238

反応式

HRID 1071238 の反応式
[Br-:1].[Br-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[Cl:22][C:23]1[CH:24]=[N:25][C:26]2[C:31]([C:32]=1O)=[CH:30][C:29]([O:34][CH3:35])=[C:28]([O:36][CH3:37])[CH:27]=2>C(#N)C>[Br:1][C:32]1[C:31]2[C:26](=[CH:27][C:28]([O:36][CH3:37])=[C:29]([O:34][CH3:35])[CH:30]=2)[N:25]=[CH:24][C:23]=1[Cl:22]

参加物

4

反応物 2

HCID 12890784Triphenylphosphane dibromideHCID 178486799HCID 178486799、化合物

生成物 1

HCID 224697664-Bromo-3-chloro-6,7-dimethoxyquinoline収率 83.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
20 °C

実験手順

19 g of triphenylphosphine dibromide were added to a solution of 5.39 g of 3-chloro-4-hydroxy-6,7-dimethoxyquinoline in 270 cm3 of acetonitrile, with stirring and at a temperature in the region of 20° C. The reaction mixture was heated at about 80° C. for 8.25 hours. After cooling to a temperature in the region of 20° C., the insoluble material was filtered off. 5.67 g of 4-bromo-3-chloro-6,7-dimethoxyquinoline were obtained in the form of a gray solid.

後処理

  1. temperatureThe reaction mixture was heated at about 80° C. for 8.25 hours
  2. temperatureAfter cooling to a temperature in the region of 20° C.
  3. filtrationthe insoluble material was filtered off

出典と根拠

ORDレコード
ord-b7d506ff08cd42379d7d2d12750909ae
出典データセット
uspto-grants-2005_06
特許番号
US06903217B2

関連ノート

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