2-Propanethiol → 5-Bromo-2-(isopropylthio)pyridine

To a mixture of 2,5-dibromopyridine (2.07 g, 8.73 mmol) and 2-propanethiol (0.97 ml, 10.4 mmol) in N,N-dimethylformamide (20 ml) at 0° C. was added portionwise sodium hydride 60% dispersed in oil (450 mg, 11.3 mmol). The resulting mixture was stirred at room temperature for 1 hour, then partitioned between ether and water. The crude product from the organic phase was chromatographed on silica gel eluting with 10% ethyl acetate in hexane to afford the 5-Bromo-2-isopropylthiopyridine compound as a solid.

1. custompartitioned between ether and water
2. customThe crude product from the organic phase was chromatographed on silica gel eluting with 10% ethyl acetate in hexane

ORDレコード

ord-2b3110ef848b4aaaa401220b511789cc

出典データセット

uspto-grants-2005_06

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06909002B2