Phenacyl bromide → 2-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone

HRID 1072511ノート

反応式

HRID 1072511 の反応式
[CH:1]1([NH:4][CH2:5][C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=2[Cl:13])[CH2:3][CH2:2]1.Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:17].C(N(CC)CC)C.BrC1C=CC(C2C3C(=C(Cl)C=C(Cl)C=3)CN(C)C2)=CC=1>O1CCOCC1>[CH:1]1([N:4]([CH2:5][C:6]2[CH:11]=[CH:10][C:9]([Cl:12])=[CH:8][C:7]=2[Cl:13])[CH2:15][C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[O:17])[CH2:2][CH2:3]1

参加物

6

反応物 4

HCID 6259Phenacyl bromideHCID 8471TriethylamineHCID 4720306Cyclopropyl-(2,4-dichloro-benzyl)-amineHCID 101772114-(4-Bromophenyl)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 223868872-[Cyclopropyl-(2,4-dichloro-benzyl)-amino]-1-phenyl-ethanone

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Intermediate 1 was reacted with alpha-bromoacetophenone in the presence of triethylamine in dioxane by the method described in example 1, intermediate 3. For workup, the solvent was distilled off, and the residue was taken up in ethyl acetate. It was washed twice with H2O and twice with 2 N HCl, dried with MgSO4 and concentrated. The crude product obtained in this way was reacted further without further purification.

後処理

  1. distillationFor workup, the solvent was distilled off
  2. washIt was washed twice with H2O and twice with 2 N HCl
  3. dry with materialdried with MgSO4
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-8cd95def416c4b37bc619ce3bc04b26b
出典データセット
uspto-grants-2005_06
特許番号
US06911453B2

反応ノート

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