Acetic Acid → 4-fluoro-3-(2-methyl-2-nitropropyl)-1H-indole

HRID 1072615

反応式

HRID 1072615 の反応式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH2:11]N(C)C)=[CH:5][NH:6]2.[OH-].[Na+].C(O)(=O)C.[N+:21]([CH:24]([CH3:26])[CH3:25])([O-:23])=[O:22]>C(OCC)(=O)C.[Cl-].[Na+].O>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4]([CH2:11][C:24]([CH3:26])([N+:21]([O-:23])=[O:22])[CH3:25])=[CH:5][NH:6]2

参加物

7

反応物 4

HCID 176Acetic AcidHCID 3982-NitropropaneHCID 14798Sodium HydroxideHCID 27744704-Fluorogramine

生成物 1

HCID 220148134-fluoro-3-(2-methyl-2-nitropropyl)-1H-indole収率 76%

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 57417360Sodium chloride; water溶媒

実験手順

A slurry of 4-fluoro-3-(dimethylaminomethyl)-1H-indole (4.3 g, 22.4 mmol) in 14.1 ml of 2-nitropropane is treated with solid NaOH (941 mg, 23.5 mmol), and the resulting mixture is heated at reflux overnight. After cooling to ambient temperature, the reaction mixture is acidified with 10% aqueous acetic acid (25 ml) and stirring is continued for 30 minutes. The reaction mixture is diluted with ethyl acetate (50 ml) and brine (50 ml). The layers are separated, and the organic layer is washed with brine (50 ml), dried over Na2SO4 and concentrated in vacuo to give 3.71 g of 4-fluoro-3-(2-methyl-2-nitropropyl)-1H-indole (76%).

後処理

  1. temperaturethe resulting mixture is heated
  2. temperatureat reflux overnight
  3. customThe layers are separated
  4. washthe organic layer is washed with brine (50 ml)
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-c436e43a9bc649c5a858135425629572
出典データセット
uspto-grants-2005_06
特許番号
US06911463B2

関連ノート

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