N-3-(4-pentylphenyl)propylphthalimide → 3-(4-Pentylphenyl)propylamine

HRID 1072716ノート

反応式

HRID 1072716 の反応式
[CH2:1]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][CH2:14][N:15]2C(=O)C3=CC=CC=C3C2=O)=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]>C(O)C.[OH-].[Na+]>[CH2:1]([C:6]1[CH:7]=[CH:8][C:9]([CH2:12][CH2:13][CH2:14][NH2:15])=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

4

反応物 1

HCID 22387439N-3-(4-pentylphenyl)propylphthalimide

生成物 1

HCID 223875943-(4-Pentylphenyl)propylamine収率 53%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 14798Sodium Hydroxide溶媒

実験手順

A solution of N-3-(4-pentylphenyl)propylphthalimide (41.1 g, 123 mmol) and hydrazinemonohydrate (9.0 ml, 185 mmol) in ethanol (300 ml) was refluxed for 3 hours. The reaction mixture was dissolved in 5N aqueous sodium hydroxide and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over magnesium sulfate anhydride, and the organic layer was concentrated to give the object compound as an oily substance. 13.5 g, (yield 53%)

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over magnesium sulfate anhydride
  4. concentrationthe organic layer was concentrated
  5. customto give the object compound as an oily substance

出典と根拠

ORDレコード
ord-9d5c4dc7bc1a49ae88ad3e74dd16d6ff
出典データセット
uspto-grants-2005_06
特許番号
US06911468B2

反応ノート

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