Pyridine → Phenol, 3-chloro-4-methyl-, acetate

HRID 1072928ノート

反応式

HRID 1072928 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[C:10](OC(=O)C)(=[O:12])[CH3:11].N1C=CC=CC=1>CCOCC>[C:10]([O:9][C:4]1[CH:5]=[CH:6][C:7]([CH3:8])=[C:2]([Cl:1])[CH:3]=1)(=[O:12])[CH3:11]

参加物

5

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 148533-Chloro-4-methylphenol

生成物 1

HCID 538898Phenol, 3-chloro-4-methyl-, acetate収率 99.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 3-chloro-4-methylphenol (500 mg) in ether (5.0 ml) were added acetic anhydride (430 mg) and pyridine (416 mg), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was washed with 1N hydrochloric acid (once) and saturated brine (twice), dried over magnesium sulfate and concentrated to dryness under reduced pressure to give the objective compound (645 mg) as a pale-yellow oil.

後処理

  1. washThe reaction mixture was washed with 1N hydrochloric acid (once) and saturated brine (twice),
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-cbe50be0c22e43b4bae2b464b757fed7
出典データセット
uspto-grants-2005_06
特許番号
US06911469B2

反応ノート

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