Sulfuryl chloride → 4-(Benzyloxy)benzene-1-sulfonyl chloride
反応式
[S:1]([Cl:5])(Cl)(=[O:3])=[O:2].[C:6]1([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>CN(C=O)C>[CH2:13]([O:12][C:6]1[CH:11]=[CH:10][C:9]([S:1]([Cl:5])(=[O:3])=[O:2])=[CH:8][CH:7]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
4
反応条件
- 温度
- 90 °C
実験手順
A 1.12 portion of anhydrous DMF is cooled to 0° C. and treated dropwise with 2.06 g of sulfuryl chloride. The resulting suspension is stirred for 30 min., then treated with 1.50 g of benzyl phenyl ether. The mixture is heated at 90° C. for 3 h, then cooled, extracted with brine and methylene chloride, and dried over MgSO4. Chormotography on silica gel (i-PrOH/hexanes) yields 4-benzyloxybenzenesulfonyl chloride.
後処理
- temperaturecooled
- extractionextracted with brine and methylene chloride
- dry with materialdried over MgSO4
出典と根拠
- ORDレコード
- ord-7b357d5bf4334f0fb405475a558ece52
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723490
反応ノート
読み込み中…