Sodium Hydroxide → Oleoyl lysophosphatidic acid

HRID 1073015ノート

反応式

HRID 1073015 の反応式
[Si]([O:18][CH:19]([CH2:41][O:42][P:43]([OH:46])([OH:45])=[O:44])[CH2:20][O:21][C:22](=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39])(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1.[OH-].[Na+]>ClCCl>[OH:18][CH:19]([CH2:41][O:42][P:43]([OH:45])([OH:46])=[O:44])[CH2:20][O:21][C:22](=[O:40])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29]/[CH:30]=[CH:31]\[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH3:39]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 69746178HCID 69746178、化合物

生成物 1

HCID 5497152Oleoyl lysophosphatidic acid収率 78%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

6 (1 mmol) is dissolved in 10 ml of dichloromethane, and 25 ml of a 1% methanolic NaOH solution is added. This is concentrated after 20 hours at room temperature, and the residue is acidified with 1N HCl. The mixture is extracted with ethyl acetate. The combined organic phases are washed with 20 ml of H2O and dried over MgSO4, filtrated and concentrated. The residue is treated with methanol. Yield: 78% of colorless crystals.

後処理

  1. concentrationThis is concentrated after 20 hours at room temperature
  2. extractionThe mixture is extracted with ethyl acetate
  3. washThe combined organic phases are washed with 20 ml of H2O
  4. dry with materialdried over MgSO4
  5. filtrationfiltrated
  6. concentrationconcentrated
  7. additionThe residue is treated with methanol

出典と根拠

ORDレコード
ord-94d1932faa0b47f6a4cd044e07f3b95c
出典データセット
uspto-grants-2005_06
特許番号
US06911553B1

反応ノート

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