Pyridine → 7-chloro-l-(2-ethylthio-3-pyridylcarbonyl)-2,3-dihydro-4(lH)-quinolinone

HRID 1073063

反応式

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[CH2:7][CH2:8][NH:9]2)=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH2:19]([S:21][C:22]1[C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=[CH:24][N:23]=1)[CH3:20]>O1CCOCC1>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[CH2:7][CH2:8][N:9]2[C:28]([C:27]2[C:22]([S:21][CH2:19][CH3:20])=[N:23][CH:24]=[CH:25][CH:26]=2)=[O:29])=[CH:4][CH:3]=1

参加物

反応条件

温度: 5 °C

実験手順

To a mixture of 7-chloro-2,3-dihydro-4(lH)-quinolinone (25 g), pyridine (32 g) and dioxane (200 ml) was added dropwise 2-ethylthio-3-pyridylcarbonyl chloride (37 under cooling at 0 C. to 5° C. with stirring. The mixture was allowed to react at room temperature for additional 3 hours. The reaction mixture was subjected to the procedure described in example 1, and 43 g of 7-chloro-l-(2-ethylthio-3-pyridylcarbonyl)-2,3-dihydro-4(lH)-quinolinone was obtained as white crystal.

後処理

temperatureunder cooling at 0 C
customto react at room temperature for additional 3 hours

出典と根拠

ORDレコード: ord-5c5615cdc391407fba391293e48e8d9b
出典データセット: uspto-grants-1990_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04968680

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート