tert-Butyl 4-benzyl-2-methylpiperazine-1-carboxylate → tert-Butyl 2-methylpiperazine-1-carboxylate

HRID 1073164

反応式

HRID 1073164 の反応式
[CH3:1][CH:2]1[CH2:7][N:6](CC2C=CC=CC=2)[CH2:5][CH2:4][N:3]1[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16].[H][H]>[Pd].CO>[CH3:1][CH:2]1[CH2:7][NH:6][CH2:5][CH2:4][N:3]1[C:15]([O:17][C:18]([CH3:19])([CH3:21])[CH3:20])=[O:16]

参加物

5

反応物 2

HCID 15087789tert-Butyl 4-benzyl-2-methylpiperazine-1-carboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 15087784tert-Butyl 2-methylpiperazine-1-carboxylate収率 94.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 85 parts of (1,1-dimethylethyl) 2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate and 400 parts of methanol was hydrogenated at normal pressure and at room temperature with 3 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 55 parts (94.6%) of (1,1-dimethylethyl) 2-methyl-1-piperazinecarboxylate as a residue (int. 42).

後処理

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

出典と根拠

ORDレコード
ord-d57d5fa6cc984cb3a2a756a04080cc7c
出典データセット
uspto-grants-1990_11
特許番号
US04968684

関連ノート

読み込み中…