Water → HCID 54249443、化合物

HRID 1073238

反応式

HRID 1073238 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:15][CH2:16][NH2:17])[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH:24]1([CH:30]=[CH:31][C:32](Cl)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1.O>C(#N)C>[CH:24]1([CH:30]=[CH:31][C:32]([NH:17][CH2:16][CH2:15][C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:10]=2)=[O:33])[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 2074152-(3-(Benzyloxy)phenyl)ethanamineHCID 566232073-Cyclohexylprop-2-enoyl chloride

生成物 1

HCID 54249443HCID 54249443、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

To a solution of 2-[3-benzyloxyphenyl]ethylamine (2.3 g) (prepared in a manner analogous to that described in Example 1E) in acetonitrile (25 cm3) was added powdered potassium carbonate (2.1 g) followed by 3-cyclohexylpropenoyl chloride (1.72 g) in acetonitrile (10 cm3) which was added over ten minutes. The resulting mixture was stirred for one hour and was then treated with water (40 cm3) and SVM (3 cm3) thereby causing the precipitation of an oil which solidified to give a pale tan solid after several minutes. This solid was filtered off, washed with 5% SVM in water and sucked dry. Yield=3.08 g m.p. 98°-100° C.

後処理

  1. additionwas added over ten minutes
  2. customthe precipitation of an oil which
  3. customto give a pale tan solid after several minutes
  4. filtrationThis solid was filtered off
  5. washwashed with 5% SVM in water
  6. customsucked dry

出典と根拠

ORDレコード
ord-6ed3d95875fb434c90d2e9397a9d6a26
出典データセット
uspto-grants-1990_11
特許番号
US04968698

関連ノート

読み込み中…