Triethylamine → N-(2-Chlorocinnamoyl)-3-propyloxyphenethylamine

HRID 1073240ノート

反応式

HRID 1073240 の反応式
[CH2:1]([O:4][C:5]1[CH:6]=[C:7]([CH2:11][CH2:12][NH2:13])[CH:8]=[CH:9][CH:10]=1)[CH2:2][CH3:3].C(OC1C=C(CCN)C=CC=1)CCC.C(N(CC)CC)C.[Cl:35][C:36]1[CH:46]=[CH:45][CH:44]=[CH:43][C:37]=1[CH:38]=[CH:39][C:40](Cl)=[O:41]>C(#N)C.O>[Cl:35][C:36]1[CH:46]=[CH:45][CH:44]=[CH:43][C:37]=1[CH:38]=[CH:39][C:40]([NH:13][CH2:12][CH2:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:5]([O:4][CH2:1][CH2:2][CH3:3])[CH:6]=1)=[O:41]

参加物

7

反応物 4

HCID 8471TriethylamineHCID 2737382HCID 2737382、化合物HCID 152056182-(3-propoxyphenyl)ethanamine(SALTDATA: HCl)HCID 22379525HCID 22379525、化合物

生成物 1

HCID 53771533N-(2-Chlorocinnamoyl)-3-propyloxyphenethylamine

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6342Acetonitrile溶媒2 回

実験手順

To a solution of 2-(3-propyloxyphenyl)ethylamine prepared in a manner analogous to that described in Example 1E (2.69 g) in acetonitrile (40 cm3) was added triethylamine (3 cm3). A solution of 2-chlorocinnamoyl chloride (3.6 g) in acetonitrile (20 cm3) was added slowly, the reaction mixture being cooled in an ice bath. When addition was complete, the mixture was stirred at room temperature for 40 minutes, treated with water (60 cm3) and SVM (2 cm3) and stirred well. The resulting precipitate was filtered off, washed and air-dried (5.49 g) m.p. 96°-99° C.

後処理

  1. temperaturethe reaction mixture being cooled in an ice bath
  2. additionWhen addition
  3. stirringstirred well
  4. filtrationThe resulting precipitate was filtered off
  5. washwashed
  6. customair-dried (5.49 g) m.p. 96°-99° C.

出典と根拠

ORDレコード
ord-e9e8ff2f67384f5b904db53b516dd7c5
出典データセット
uspto-grants-1990_11
特許番号
US04968698

反応ノート

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