Sodium Hydroxide → cis-dichloro-(3R)-3-aminopyrrolidine platinum (II)

HRID 1073312ノート

反応式

HRID 1073312 の反応式
C([C@H]([C@@H](C(O)=O)O)O)(O)=O.[NH2:11][C@@H:12]1[CH2:16][CH2:15][NH:14][CH2:13]1.[OH-].[Na+].[Cl-:19].[K+].[Pt+2:21].[Cl-:22].[Cl-]>O>[Pt+2:21].[Cl:19][C@@H:13]1[C@H:12]([NH2:11])[CH2:16][CH2:15][N:14]1[Cl:22]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 15107948(3R)-3-Aminopyrrolidine D(-)-tartrateHCID 86744074platinum (II) potassium chloride

生成物 1

HCID 18640044cis-dichloro-(3R)-3-aminopyrrolidine platinum (II)収率 57.2%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

(3R)-3-Aminopyrrolidine D(-)-tartrate (236 mg) prepared in Reference Example 1-(1) is dissolved in water (40 ml) and thereto is added sodium hydroxide (80 mg), and the mixture is stirred at room temperature. To the solution is added platinum (II) potassium chloride (415 mg), and the mixture is stirred at room temperature overnight. The precipitated solid is removed by filtration, and the filtrate is concentrated under reduced pressure. To the residue is added water (2 ml), and the resulting crystals are separated by filtration and washed with water and acetone to give cis-dichloro-(3R)-3-aminopyrrolidine platinum (II) (200 mg) as pale yellow crystal.

後処理

  1. stirringthe mixture is stirred at room temperature overnight
  2. customThe precipitated solid is removed by filtration
  3. concentrationthe filtrate is concentrated under reduced pressure
  4. additionTo the residue is added water (2 ml)
  5. customthe resulting crystals are separated by filtration
  6. washwashed with water and acetone

出典と根拠

ORDレコード
ord-4169bbb3c4154d2ba7bf6498c53b602a
出典データセット
uspto-grants-1990_11
特許番号
US04968800

反応ノート

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