Hydrochloric Acid → 125960-58-9
反応式
FC(F)(F)C([NH:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([NH2:17])(=[O:16])=[O:15])[CH:13]=1)=O.[OH-].[Na+].[ClH:24]>CO>[ClH:24].[NH2:5][CH2:6][CH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:18][CH3:19])=[C:12]([S:14]([NH2:17])(=[O:16])=[O:15])[CH:13]=1参加物
5
実験手順
To a suspension of 10.0 g of 5-[2-(trifluoroacetylamino)ethyl]-2-methoxybenzenesulfonamide in 100 ml of methanol were added 60 ml of 10% sodium hydroxide aqueous solution with stirring at room temperature and the reaction mixture was stirred for 30 minutes. The reaction mixture was acidfied with 13 ml of hydrochloric acid. The precipitate was filtered and recrystallized from water to give 4.22 g of the desired compound as colorless needles, m.p. 263°-266° C.
後処理
- stirringthe reaction mixture was stirred for 30 minutes
- filtrationThe precipitate was filtered
- customrecrystallized from water
出典と根拠
- ORDレコード
- ord-35e5f50572eb4355a73dfd2f0697db81
- 出典データセット
- uspto-grants-1990_11
- 特許番号
- US04971990
反応ノート
読み込み中…