Ethylene carbonate → 2-(5-Fluoro-2-methoxyphenoxy)ethanol
反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([OH:8])[CH:7]=1.C1(=O)O[CH2:14][CH2:13][O:12]1.C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.C1C=CC=CC=1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:9][CH3:10])=[C:6]([CH:7]=1)[O:8][CH2:14][CH2:13][OH:12]参加物
6
実験手順
A suspension of 8.75 g of 5-fluoro-2-methoxyphenol, 10.9 g of ethylene carbonate and 8.50 g of potassium carbonate in 12 ml of toluene was refluxed for 2.5 hours. The reaction mixture was diluted with benzene, washed with water, dried and evaporated. The residue was distilled to give 9.15 g of 2-(5-fluoro-2-methoxyphenoxy)ethanol as colorless oil, b.p. 138°-140° C. (8mmHg).
後処理
- temperaturewas refluxed for 2.5 hours
- washwashed with water
- customdried
- customevaporated
- distillationThe residue was distilled
出典と根拠
- ORDレコード
- ord-b9a9945b2083473f800340acad563587
- 出典データセット
- uspto-grants-1990_11
- 特許番号
- US04971990
反応ノート
読み込み中…