Hydrazine hydrate (1:1) → HCID 11159719、化合物

HRID 1073853ノート

反応式

HRID 1073853 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[O:7][CH2:8][CH2:9][N:10]1C(=O)C2=CC=CC=C2C1=O.O.NN>C(O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:22][CH3:23])=[C:6]([CH:21]=1)[O:7][CH2:8][CH2:9][NH2:10]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 22157077HCID 22157077、化合物

生成物 1

HCID 11159719HCID 11159719、化合物収率 64.9%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A suspension of 10.0 g of N-[2-(5-fluoro-2-methoxyphenoxy)ethyl]phthalimide and 5.14 ml 5.14 ml of hydrazine hydrate in 100 ml of ethanol was heated for 1 hour at 50°-60° C. After cooling, the precipitate was filtered off and the filtrate was evaporated. The residue was diluted with water and extracted with chloroform. The extract was washed with water, dried and evaporated. The residue was distilled to give 3.81 g of the desired compound as a colorless oil, b.p. 126°-127° C. (9 mmHg).

後処理

  1. temperaturewas heated for 1 hour at 50°-60° C
  2. temperatureAfter cooling
  3. filtrationthe precipitate was filtered off
  4. customthe filtrate was evaporated
  5. additionThe residue was diluted with water
  6. extractionextracted with chloroform
  7. washThe extract was washed with water
  8. customdried
  9. customevaporated
  10. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-1ce6df1f218d486a88a2077d4b7debdc
出典データセット
uspto-grants-1990_11
特許番号
US04971990

反応ノート

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