Sodium borohydride → HCID 19895686、化合物

HRID 1073953

反応式

HRID 1073953 の反応式
[BH4-].[Na+].[OH:3][C:4](=[CH:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][N:19]=1)[C:5]([CH3:16])([CH3:15])[O:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1>C(O)C>[OH:3][CH:4]([CH2:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][N:19]=1)[C:5]([CH3:15])([CH3:16])[O:6][C:7]1[CH:8]=[CH:9][C:10]([C:11]#[N:12])=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 1364045254-[2-Hydroxy-1,1-dimethyl-3-(4-pyrimidinyl)-2-propenyloxy]benzonitrile

生成物 1

HCID 19895686HCID 19895686、化合物収率 73,959.797%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
20 °C

実験手順

0.013 mg of sodium borohydride was added to a solution of 0.098 mg of 4-[2-hydroxy-1,1-dimethyl-3-(4-pyrimidinyl)-2-propenyloxy]benzonitrile in 3 ml of ethanol and the solution was stirred at 20° C. for 16 hours. The solvent was removed by evaporation and the residue was partitioned between ethyl acetate and water. The organic phase was evaporated and the residue was chromatographed on silica gel using ethyl acetate for the elution. There was obtained 0.073 g of 4-[2-hydroxy-1,1-dimethyl-3-(4-pyrimidinyl)propoxy]benzonitrile in the form of a white solid of melting point 96°-98° C.

後処理

  1. customThe solvent was removed by evaporation
  2. customthe residue was partitioned between ethyl acetate and water
  3. customThe organic phase was evaporated
  4. customthe residue was chromatographed on silica gel
  5. washfor the elution

出典と根拠

ORDレコード
ord-043738df25ec4b82aaf4257a235dcd73
出典データセット
uspto-grants-1990_11
特許番号
US04971982

関連ノート

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