Sodium borohydride → 4-[2-Hydroxy-1,1-dimethyl-3-(2-pyrazinyl)propoxy]benzonitrile

HRID 1073958ノート

反応式

HRID 1073958 の反応式
[BH4-].[Na+].[CH3:3][C:4]([CH3:23])([O:14][C:15]1[CH:22]=[CH:21][C:18]([C:19]#[N:20])=[CH:17][CH:16]=1)[C:5](=[O:13])[CH2:6][C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1>C(O)C.O>[OH:13][CH:5]([CH2:6][C:7]1[CH:12]=[N:11][CH:10]=[CH:9][N:8]=1)[C:4]([CH3:3])([CH3:23])[O:14][C:15]1[CH:16]=[CH:17][C:18]([C:19]#[N:20])=[CH:21][CH:22]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 198956054-[1,1-Dimethyl-2-oxo-3-(2-pyrazinyl)propoxy]benzonitrile

生成物 1

HCID 198956134-[2-Hydroxy-1,1-dimethyl-3-(2-pyrazinyl)propoxy]benzonitrile収率 62.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
20 °C

実験手順

0.107 g of sodium borohydride was added to a stirred suspension of 0.79 g of 4-[1,1-dimethyl-2-oxo-3-(2-pyrazinyl)propoxy]benzonitrile in 20 ml of ethanol. The mixture was stirred at 20° C. for 1.5 hours and was then diluted with water. The solution was extracted with ethyl acetate and the organic phase was then washed with sodium chloride solution and evaporated to give 0.5 g of 4-[2-hydroxy-1,1-dimethyl-3-(2-pyrazinyl)propoxy]benzonitrile in the form of a white solid of melting point 94°-95° C. (from diethyl ether).

後処理

  1. extractionThe solution was extracted with ethyl acetate
  2. washthe organic phase was then washed with sodium chloride solution
  3. customevaporated

出典と根拠

ORDレコード
ord-3a7f10286aca492d95da22c3a618a741
出典データセット
uspto-grants-1990_11
特許番号
US04971982

反応ノート

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