Phenol → Phenol

HRID 1074221

反応式

HRID 1074221 の反応式
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.ClC(Cl)CCl.[F:13][N+]1C(S([O-])(=O)=O)=CC=CC=1Cl>>[F:13][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=1[OH:7].[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 996PhenolHCID 65741,1,2-TrichloroethaneHCID 14897827N-Fluoro-6-chloropyridinium-2-sulfonate

生成物 2

HCID 996PhenolHCID 97072-Fluorophenol

実験手順

A 25 ml egg-plant type flask was flushed with argon, and 42.4 mg (0.45 mmol) of phenol, 2 ml of dry 1,1,2-trichloroethane and 95.3 mg (0.45 mmol) of N-fluoro-2-chloropyridinium-6-sulfonate were charged. The flask was immersed in an oil bath of 100° C. and heated for 49 hours. After completion of the reaction, the reaction solution was washed with water to remove 2-chloropyridine-6-sulfonic acid. The organic layer was quantitatively analyzed by gas chromatography. o-Fluorophenol was obtained at a conversion yield of 58%, and phenol was recovered at a recovery rate of 5%.

後処理

  1. additionwere charged
  2. customThe flask was immersed in an oil bath of 100° C.
  3. temperatureheated for 49 hours
  4. customAfter completion of the reaction
  5. washthe reaction solution was washed with water
  6. customto remove 2-chloropyridine-6-sulfonic acid

出典と根拠

ORDレコード
ord-f5911b1e5b8140889c928cace3bd7b3a
出典データセット
uspto-grants-1990_11
特許番号
US04973697

関連ノート

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