Phenacyl bromide → (2-Oxo-2-phenylethyl)(triphenyl)phosphanium bromide

HRID 1074259ノート

反応式

HRID 1074259 の反応式
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[C:11]1([P:17]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1>[Br-:1].[O:4]=[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:2][P+:17]([C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1)([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

4

反応物 2

HCID 6259Phenacyl bromideHCID 11776Triphenylphosphine

生成物 1

HCID 197064(2-Oxo-2-phenylethyl)(triphenyl)phosphanium bromide収率 93.3%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

50.0 g. (251mmoles) of α-bromoacetophenone (Compound CI) and 65.9 g. (251 mmoles) of triphenylphosphine are stirred in 500 ml. of toluene at 20°-25° C. under nitrogen for 16 hours, and the resulting solid is collected by filtration, rinsed with toluene and rinsed with diethyl ether to obtain the product as a white powder (107.98 g. (93%)).

後処理

  1. filtrationthe resulting solid is collected by filtration
  2. washrinsed with toluene
  3. washrinsed with diethyl ether

出典と根拠

ORDレコード
ord-326ceb0eb86c41169175edd1c1c7e54f
出典データセット
uspto-grants-1990_11
特許番号
US04973704

反応ノート

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