Triethylamine → Ethyl 3-ethoxy-3-imino-2-(cyclopropyloxyimino)propionate

HRID 1074340

反応式

HRID 1074340 の反応式
[C:1]([C:4](=[N:10][O:11][CH:12]1[CH2:14][CH2:13]1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])(=[O:3])[NH2:2].F[B-](F)(F)F.[CH2:20]([O+](CC)CC)[CH3:21].C(N(CC)CC)C>C(Cl)Cl.C(OC(C)C)(C)C>[CH2:20]([O:3][C:1](=[NH:2])[C:4](=[N:10][O:11][CH:12]1[CH2:13][CH2:14]1)[C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH3:21]

参加物

6

反応物 3

HCID 8471TriethylamineHCID 2723982Triethyloxonium tetrafluoroborateHCID 54332569Ethyl 2-carbamoyl-2-(cyclopropyloxyimino)acetate

生成物 1

HCID 54045971Ethyl 3-ethoxy-3-imino-2-(cyclopropyloxyimino)propionate収率 69.5%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 7914Diisopropyl Ether溶媒

実験手順

A mixture of ethyl 2-carbamoyl-2-(cyclopropyloxyimino)acetate (syn isomer)(84.1 g) and triethyloxonium fluoroborate (11.5 g) in methylene chloride (110 ml) was stirred at ambient temperature for 16 hours. To the mixture was added triethylamine (17 ml) under ice-cooling. The mixture was washed with water, dried over sodium sulfate, and concentrated in vacuo to give a residue. The residue was dissolved in diisopropyl ether. The solution was washed with water, dried over sodium sulfate, and concentrated in vacuo to give ethyl 3-ethoxy-3-imino-2-(cyclopropyloxyimino)propionate (syn isomer) (9.60 g) as an oil.

後処理

  1. temperaturecooling
  2. washThe mixture was washed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customto give a residue
  6. washThe solution was washed with water
  7. dry with materialdried over sodium sulfate
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-9b55814a15714c82b1b99405d98beb96
出典データセット
uspto-grants-1990_11
特許番号
US04973699

関連ノート

読み込み中…