Pyrrolidine → 6-(1-Pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

HRID 1074391ノート

反応式

HRID 1074391 の反応式
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][CH:13]=[CH:14][N:4]2[N:3]=1.[NH:15]1[CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][CH:13]=[CH:14][N:4]3[N:3]=2)[CH2:19][CH2:18][CH2:17][CH2:16]1

参加物

3

反応物 2

HCID 31268PyrrolidineHCID 131789756-Chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

生成物 1

HCID 131789766-(1-Pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

実験手順

A mixture was prepared by adding 4.5 g of 6-chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine to 8.7 g of pyrrolidine and this was heated at reflux for 6.5 hours during which time the mixture turned brown. The reaction mixture was then poured into about 150 ml of ice water. A solid formed immediately and this was separated by filtration and air dried to give 6-(1-pyrrolidinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine melting at about 128° C.

後処理

  1. customA mixture was prepared
  2. temperaturethis was heated
  3. temperatureat reflux for 6.5 hours during which time the mixture
  4. customA solid formed immediately
  5. customthis was separated by filtration and air
  6. customdried

出典と根拠

ORDレコード
ord-3d058b71237d4773ac9fe46eeb6fab86
出典データセット
uspto-grants-1983_07
特許番号
US04391807

反応ノート

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