1-Methylpiperazine → 6-(4-Methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

HRID 1074393ノート

反応式

HRID 1074393 の反応式
Cl[C:2]1[C:11]2[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=2[C:5]2=[N:12][CH:13]=[CH:14][N:4]2[N:3]=1.[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[C:11]3[CH2:10][CH2:9][CH2:8][CH2:7][C:6]=3[C:5]3=[N:12][CH:13]=[CH:14][N:4]3[N:3]=2)[CH2:18][CH2:17]1

参加物

3

反応物 2

HCID 531671-MethylpiperazineHCID 131789756-Chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

生成物 1

HCID 131789786-(4-Methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine

実験手順

A mixture of 15 g of 6-chloro-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine and 36.2 g of 1-methylpiperazine was heated at reflux for 48 hours during which time the reaction mixture turned brown. The reaction was poured into about 150 ml of ice water. The solid which formed was separated by filtration and air-dried to give 6-(4-methyl-1-piperazinyl)-7,8,9,10-tetrahydroimidazo[2,1-a]phthalazine melting at about 79.5° C.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 48 hours during which time the reaction mixture
  3. customThe solid which formed
  4. customwas separated by filtration
  5. customair-dried

出典と根拠

ORDレコード
ord-8d2f3a9a111541c88a29b7a49eca0cdd
出典データセット
uspto-grants-1983_07
特許番号
US04391807

反応ノート

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