Sodium benzenethiolate → 2-Chloro-3-phenylthio-6-nitro-N-methylaniline

HRID 1074848

反応式

HRID 1074848 の反応式
[C:1]1([S-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[Cl:9][C:10]1[C:17](Cl)=[CH:16][CH:15]=[C:14]([N+:19]([O-:21])=[O:20])[C:11]=1[NH:12][CH3:13]>C(#N)C>[Cl:9][C:10]1[C:17]([S:7][C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:16][CH:15]=[C:14]([N+:19]([O-:21])=[O:20])[C:11]=1[NH:12][CH3:13]

参加物

4

反応物 2

HCID 4110039Sodium benzenethiolateHCID 204396362,3-dichloro-N-methyl-6-nitroaniline

生成物 1

HCID 204950262-Chloro-3-phenylthio-6-nitro-N-methylaniline

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

An amount of 2.9 gm of sodium thiophenolate was added to a solution of 4.4 gm (0.02 mol) of 2,3-dichloro-6-nitro-N-methylaniline dissolved in 50 ml of acetonitrile. The mixture was refluxed for half an hour and subsequently evaporated, and the residue was taken up with chloroform and water. The chloroform layer was separated, dried, and evaporated. Six grams of brown oil, which crystallized with isopropanol, were obtained. The yield from the crystallization was 4 gm of product (67.5% of theory) in the form of yellow crystals, m.p. 79° C.

後処理

  1. temperatureThe mixture was refluxed for half an hour
  2. customsubsequently evaporated
  3. customThe chloroform layer was separated
  4. customdried
  5. customevaporated
  6. customSix grams of brown oil, which crystallized with isopropanol
  7. customwere obtained
  8. customThe yield from the crystallization

出典と根拠

ORDレコード
ord-f2d4cd2ada3d4c7b835e61681b1ae5d2
出典データセット
uspto-grants-1983_07
特許番号
US04394159

関連ノート

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