1-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one → 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

HRID 1074894

反応式

HRID 1074894 の反応式
[N:1]1([CH2:6][C:7]([C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[O:8])[CH:5]=[N:4][CH:3]=[N:2]1.[BH4-].[Na+]>CO>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([CH:7]([OH:8])[CH2:6][N:1]2[CH:5]=[N:4][CH:3]=[N:2]2)=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 7164721-(4-Chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-oneHCID 4311764Sodium borohydride

生成物 1

HCID 5580621-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A suspension of α-1,2,4-triazol-1-yl-p-chloroacetophenone (4 g) in methanol (12 ml) was treated with sodium borohydride (0.5 g) with cooling and stirring. The mixture was then left at room temperature for 0.5 hour and refluxed for 1 hour. The methanol was removed under reduced pressure and water (25 ml) was added followed by dilute hydrochloric acid (10 ml). The white solid was filtered, washed with water and dried. Crystallisation from ethyl acetate-petroleum ether (60°-80°) gave the title compound as a white crystalline solid. Analysis:

後処理

  1. temperaturewith cooling
  2. temperaturerefluxed for 1 hour
  3. customThe methanol was removed under reduced pressure and water (25 ml)
  4. additionwas added
  5. filtrationThe white solid was filtered
  6. washwashed with water
  7. customdried
  8. customCrystallisation from ethyl acetate-petroleum ether (60°-80°)

出典と根拠

ORDレコード
ord-aec6030bdd3e4464948156ea7dbc710f
出典データセット
uspto-grants-1983_07
特許番号
US04394380

関連ノート

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