Butyl bromide → 1-p-Chlorophenyl-1-n-butoxy-2-(1,2,4-triazol-1-yl)ethane

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:15])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1.[H-].[Na+].[CH2:18](Br)[CH2:19][CH2:20][CH3:21]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:15][CH2:18][CH2:19][CH2:20][CH3:21])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1

参加物

反応物 3

HCID 8002Butyl bromide

HCID 24758Sodium hydride

HCID 5580621-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

生成物 1

HCID 136554241-p-Chlorophenyl-1-n-butoxy-2-(1,2,4-triazol-1-yl)ethane

実験手順

Following the procedure of Example 9, Step 2, 1-p-chlorophenyl-2-(1,2,4-triazol-1-yl)-ethanol (2.23 g), sodium hydride (440 mg; 50%) and n-butyl bromide (1.37 g) were reacted to give the title compound as an oil. Analysis:

後処理

customwere reacted

出典と根拠

ORDレコード: ord-f8766b1edbf4478190b8cfb59e50db83
出典データセット: uspto-grants-1983_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04394380

反応ノート

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