Benzyl Chloride → 1-p-Chlorophenyl-1-benzyloxy-2-(1,2,4-triazol-1-yl)-ethane

反応式

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([OH:15])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1.[CH2:16](Cl)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[H-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1

参加物

反応物 3

HCID 7503Benzyl Chloride

HCID 24758Sodium hydride

HCID 5580621-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol

生成物 1

HCID 204952321-p-Chlorophenyl-1-benzyloxy-2-(1,2,4-triazol-1-yl)-ethane

実験手順

Following the procedure of Example 9, Step 2, 1-p-chlorophenyl-2-(1,2,4-triazol-1-yl)-ethanol (4.48 g), benzyl chloride (2.54 g) and sodium hydride (1 g; 50%) were reacted to give the title compound as a crystalline solid. Analysis: