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Ethane → N-(2-benzylthioethyl)nicotinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethane | HCID 6324 | — |
| 反応物 | 2-(Benzylsulfanyl)ethan-1-amine | HCID 31198 | — |
| 反応物 | Ethyl Nicotinate | HCID 69188 | — |
| 生成物 | N-(2-benzylthioethyl)nicotinamide | HCID 20495567 | — |
反応手順
30 grams of ethyl nicotinate and 80 grams of 2-benzylthio ethylamine are heated for 12 hours at 170°-180° C. The ethane liberated during the reaction is removed by means of a Dean Stark apparatus. After cooling, the reaction mixture is dissolved in 400 cc of carbon tetrachloride; by addition of petroleum ether, the N-(2-benzylthioethyl)nicotinamide crystallizes: 47 g. By crystallization in a mixture of carbon tetrachloride and cyclohexane, there are recovered colorless crystals of the above product melting at 79° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04394520 |
| 出典データセット | uspto-grants-1983_07 |
| ORD ID | ord-ad9243e8516948e18e4b28ea6ec3827a |
| 出典メモ | uspto-grants-1983_07 |