Borane → 3-Hydroxymethyl-10,11-dihydro-11-oxodibenzo[b,f]-thiepin
反応式
[O:1]=[C:2]1[CH2:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[S:5][C:4]2[CH:13]=[C:14]([C:17](O)=[O:18])[CH:15]=[CH:16][C:3]1=2.B.C(OCC)(=O)C>O1CCCC1.O>[OH:18][CH2:17][C:14]1[CH:15]=[CH:16][C:3]2[C:2](=[O:1])[CH2:8][C:7]3[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=3[S:5][C:4]=2[CH:13]=1参加物
6
実験手順
Dissolve 5.1 gm. of 10,11-dihydro-11-oxodibenzo[b,f]thiepin-3-carboxylic acid in 100 cc. of tetrahydrofuran and add 35 cc. of 1M borane in tetrahydrofuran at room temperature under a nitrogen atmosphere. Stir the mixture at room temperature for 3 hours. Slowly dilute the reaction mixture with water and then with ethyl acetate. Wash with aqueous sodium chloride, dry and evaporate to an oil.
後処理
- dissolutionDissolve 5.1 gm
- customat room temperature
- washWash with aqueous sodium chloride
- customdry
- customevaporate to an oil
出典と根拠
- ORDレコード
- ord-bb68a86f61774eafb9c9a82a3f8f387b
- 出典データセット
- uspto-grants-1983_07
- 特許番号
- US04394515
反応ノート
読み込み中…