Methylamine → HCID 178482511、化合物

HRID 1075060

反応式

HRID 1075060 の反応式
[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10]O)[N:9]=1)[CH3:3].Cl.[SH:13][CH2:14][CH2:15][CH2:16][NH2:17].CO[C:20]1[C:24](OC)=[N:23][S:22](=[O:28])(=[O:27])[N:21]=1.[CH3:29][NH2:30]>Br>[CH3:1][N:2]([CH2:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][S:13][CH2:14][CH2:15][CH2:16][NH:17][C:20]2[C:24]([NH:30][CH3:29])=[N:23][S:22](=[O:28])(=[O:27])[N:21]=2)[N:9]=1)[CH3:3]

参加物

6

反応物 4

HCID 6329MethylamineHCID 197870(3-Mercaptopropyl)ammonium chlorideHCID 1838020(2-((Dimethylamino)methyl)thiazol-4-yl)methanolHCID 122305383,4-Dimethoxy-1,2,5-thiadiazole 1,1-dioxide

生成物 1

HCID 178482511HCID 178482511、化合物

試薬・触媒・溶媒 1

HCID 260Hydrogen Bromide溶媒

実験手順

When 2-dimethylaminomethyl-4-hydroxymethylthiazole [prepared in Example 34, Step D] is reacted with 3-mercaptopropylamine hyrochloride [prepared according to the procedure described in J. Org. Chem., 27, 2846 (1962)] in aqueous hydrobromic acid (48%), and the resultant amine is successively treated with 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide and excess methylamine as in the general procedure of Example 31, the title compound is produced.

後処理

  1. customprepared

出典と根拠

ORDレコード
ord-18c292dfca954221bfdf601dfca5224e
出典データセット
uspto-grants-1983_07
特許番号
US04394508

関連ノート

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