Cysteamine Hydrochloride → HCID 15592302、化合物

HRID 1075077

反応式

HRID 1075077 の反応式
Cl.[NH2:2][CH2:3][CH2:4][SH:5].C[O-].[Na+].Cl[CH2:10][C:11]1[N:15]=[C:14]([CH3:16])[O:13][N:12]=1>CO>[CH3:16][C:14]1[O:13][N:12]=[C:11]([CH2:10][S:5][CH2:4][CH2:3][NH2:2])[N:15]=1

参加物

5

反応物 3

HCID 9082Cysteamine HydrochlorideHCID 3021573-(Chloromethyl)-5-methyl-1,2,4-oxadiazoleHCID 10942334Sodium Methoxide

生成物 1

HCID 15592302HCID 15592302、化合物収率 121.9%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

Cysteamine hydrochloride (3.03 g; 26.7 mmoles) was added in several portions over a period of 10 minutes to a stirred solution of sodium methylate (2.89 g; 53.4 mmoles) in 50 ml of methanol at 0°. After stirring for 70 minutes at 0°, a solution of 3-chloromethyl-5-methyl-1,2,4-oxadiazole (3.54 g; 26.7 mmoles) in 15 ml of methanol was added dropwise over a period of 15 minutes, and the reaction mixture was allowed to stir at ambient temperature for 16 hours. The mixture was filtered, evaporated and redissolved in isopropyl alcohol, then filtered and evaporated under reduced pressure to give the title compound (5.64 g) as a yellow oil. The NMR spectrum (60 MHz) in CDCl3 gave the following resonances δ: 3.77 (s, 2H); 2.77 (m, 4H); 2.63 (s, 3H).

後処理

  1. stirringto stir at ambient temperature for 16 hours
  2. filtrationThe mixture was filtered
  3. customevaporated
  4. dissolutionredissolved in isopropyl alcohol
  5. filtrationfiltered
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-bbce1a95f8ca40b4a134bbc7e1a36c13
出典データセット
uspto-grants-1983_07
特許番号
US04394508

関連ノート

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