Cysteamine Hydrochloride

HCID 9082CAS 156-57-0

部分構造検索類似構造を探す

基本情報

標準SMILES: Cl.NCCS
InChIKey: OGMADIBCHLQMIP-UHFFFAOYSA-N
分子式: C2H7NS.ClH
平均分子量: 113.61 g/mol
単同位体質量: 113.00659794

概要

Cysteamine hydrochloride is an alkanethiol.

名称と識別子

優先名称: Cysteamine Hydrochloride
IUPAC: 2-aminoethanethiol;hydrochloride

名称と別名

Cysteamine hydrochloride156-57-02-Aminoethanethiol hydrochlorideCysteamine HClMercaptamine hydrochlorideCysteaminium chlorideBekaptanETHANETHIOL, 2-AMINO-, HYDROCHLORIDEMercaptoethylamine hydrochlorideMerkamin hydrochlorideMercamine hydrochlorideCysteamine chlorohydrate

名称をさらに表示

CysteaminhydrochloridCystaranDTXSID8045779IF1B771SVBNSC-758692CI-9148CYSTADROPSNSC-21116

データベース識別子

CAS: 156-57-0、16904-32-8
PubChem CID: 9082
DTXSID: DTXSID8045779
ChEMBL: CHEMBL1256137
ChEBI: CHEBI:201814
UNII: IF1B771SVB
EC Number: 205-858-1

物性

構造計算による物性

極性表面積: 27 Å²
水素結合供与体数: 3
水素結合受容体数: 2
回転可能結合数: 1
重原子数: 5
形式電荷: 0
複雑度: 10

実験および物理化学的性質

Chemical ClassesBiological Agents -> Amino Acids and Derivatives

CosmeticsReducing; Antioxidant

Solubility>17 [ug/mL] (The mean of the results at pH 7.4)

Human Drugs · 3 件

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine (Orphan designations)

FDA approved drugs -> Active ingredient

Physical DescriptionSolid; [Merck Index] White hygroscopic crystals; [Alfa Aesar MSDS]

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 6.1% (17 of 278) of reports.

Warning

H302 (92.1%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 278 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 3 件

Chemical: Ethanethiol, 2-amino-, hydrochloride

Status: Active Update: 28-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25700

Ethanethiol, 2-amino-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Hazards Summary · 1 件

Causes burns to skin and eyes; A respiratory tract irritant; [ECHA REACH Registrations] Teratogenicity observed in oral study of rats in the absence of maternal toxicity; Developmental toxicity observed in intraperitoneal study of mice; [Shepard's Catalog of Teratogenic Agents] A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS]

Hazard Classes and CategoriesAcute Tox. 4 (92.1%)

毒性情報

Adverse EffectsDermatotoxin - Skin burns.

化学と産業

薬理情報

FDA Pharmacological Classification · 2 件

CYSTEAMINE HYDROCHLORIDE

Cystine Disulfide Reduction [MoA]; Cystine Depleting Agent [EPC]

MeSH Pharmacological ClassificationCompounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS.

用途と製造

Uses · 1 件

Cysteamine is a natural antioxidant, precursor in taurine biosynthesis, and component of coenzyme A; Used in medical research (potent ulcerogen), as a drug (nephropathic cystinosis), and antidote (acetaminophen poisoning); [Merck Index] A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. [ChemIDplus] Used as an intermediate; [ECHA REACH Registrations]

Use ClassificationCosmetics -> Reducing; Antioxidant

General Manufacturing InformationEthanethiol, 2-amino-, hydrochloride (1:1): ACTIVE