2-アミノエタンチオール塩酸塩
Cysteamine Hydrochloride
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基本情報
- CAS
156-57-0- 標準SMILES
Cl.NCCS- InChIKey
OGMADIBCHLQMIP-UHFFFAOYSA-N- 分子式
- C2H7NS.ClH
- 平均分子量
- 113.61 g/mol
- 単同位体質量
- 113.00659794
概要
Cysteamine hydrochloride is an alkanethiol.
名称と識別子
- 優先名称
- Cysteamine Hydrochloride
- IUPAC
- 2-aminoethanethiol;hydrochloride
- 現地名
- 2-アミノエタンチオール塩酸塩
- 英語名
- Cysteamine hydrochloride
- 分子式
- C2H8ClNS
- 分子量
- 113.61
名称と別名
Cysteamine hydrochloride156-57-02-Aminoethanethiol hydrochlorideCysteamine HClMercaptamine hydrochlorideCysteaminium chlorideBekaptanETHANETHIOL, 2-AMINO-, HYDROCHLORIDEMercaptoethylamine hydrochlorideMerkamin hydrochlorideMercamine hydrochlorideCysteamine chlorohydrate
名称をさらに表示
2-アミノエタンチオール塩酸塩2-アミノ-1-エタンチオール·塩酸システアミン·塩酸2-メルカプトエチルアミン·塩酸塩2-アミノエタンチオール·塩酸塩2-アミノエタンチオール·塩酸システアミン塩酸塩2-アミノエタン-1-チオール·塩酸塩β-メルカプトエチルアミン塩酸2-メルカプトエチルアミン塩酸塩チオエタノールアミン塩酸塩2-メルカプトエチルアミン塩酸塩(2-アミノエタンチオール塩酸塩)2-アミノエタンチオール＝塩酸塩システアミンHCL2‐アミノエタンチオール塩酸塩(塩酸2‐アミノエタンチオール)2-アミノエタン-1-チオール塩酸塩システアミン 塩酸塩2-アミノエタンチオール塩酸塩(塩酸2-アミノエタンチオール)2-MERCAPTOETHYLAMINE HYDROCHLORIDE2-AMINOETHANE-1-THIOL HYDROCHLORIDEAminoethanethiol hydrochloridemercaptoethylammonium chloride2-Mercaptoethylammonium chlorideL-Cysteamine hydrochloride2-AMINOETHANETHIOL HCL
CysteaminhydrochloridCystaranDTXSID8045779IF1B771SVBNSC-758692CI-9148CYSTADROPSNSC-21116
データベース識別子
- CAS
156-57-0、16904-32-8- PubChem CID
- 9082
- DTXSID
DTXSID8045779- ChEMBL
CHEMBL1256137- ChEBI
CHEBI:201814- UNII
- IF1B771SVB
- EC Number
- 205-858-1
物性
構造計算による物性補完中
- 極性表面積
- 27 Ų
- 水素結合供与体数
- 3
- 水素結合受容体数
- 2
- 回転可能結合数
- 1
- 重原子数
- 5
- 形式電荷
- 0
- 複雑度
- 10
実験および物理化学的性質
Chemical ClassesBiological Agents -> Amino Acids and Derivatives
CosmeticsReducing; Antioxidant
Solubility>17 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine (Orphan designations)
FDA approved drugs -> Active ingredient
Physical DescriptionSolid; [Merck Index] White hygroscopic crystals; [Alfa Aesar MSDS]
物理化学的性質
- 融点
- 67 · 67-71 °C
- 沸点
- 238.5 ℃[at · 238.5℃[at 101 325 Pa]
- 比重(密度)
- 0.75 · 0.75
- 蒸気圧
- 5.333 Pa · 5.333Pa at 25℃
- 屈折率
- 1.61 · 1.6100 (estimate)
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 2 O: · H2O: 1M at20℃、透明、無色
- 外見
- 結晶性粉末またはペレット
- 色
- 白い
- PH
- 3.3 · 3.3-5.0 (400g/l, H2O, 20℃)
- 由来生物
- synthetic (organic)
- 水溶解度
- 非常に溶けやすい
- Merck
- 14 · 14,2779
- BRN
- 3590083 · 3590083
- 安定性
- 安定していますが、吸湿性があります。強力な酸化剤とは相容れない。
- 化粧品成分の機能
- 抗酸化物質還元剤ヘアウェーブとヘアストレート
- InChI
- 1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H
- InChIKey
- OGMADIBCHLQMIP-UHFFFAOYSA-N
- SMILES
- Cl[H].NCCS
- LogP
- -2.14 at · -2.14 at 25℃
- CAS データベース
- 156 · 156-57-0(CAS DataBase Reference)
- EPAの化学物質情報
- Cysteamine hydrochloride (156-57-0)
- Absorption
- 270 nm · cut-off at 270nm in H2O at 1M
化学的性質
化学的特性White Solid
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
This chemical does not meet GHS hazard criteria for 6.1% (17 of 278) of reports.
Warning
H302 (92.1%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 278 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Regulatory Information
Chemical: Ethanethiol, 2-amino-, hydrochloride
Status: Active Update: 28-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/25700
Ethanethiol, 2-amino-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Hazards Summary
Causes burns to skin and eyes; A respiratory tract irritant; [ECHA REACH Registrations] Teratogenicity observed in oral study of rats in the absence of maternal toxicity; Developmental toxicity observed in intraperitoneal study of mice; [Shepard's Catalog of Teratogenic Agents] A skin and strong eye irritant; Harmful by ingestion; [Alfa Aesar MSDS]
Hazard Classes and CategoriesAcute Tox. 4 (92.1%)
毒性情報
Adverse EffectsDermatotoxin - Skin burns.
安全データ
- F
- 1-3-10-13
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- KJ0200000
- ridadr
- UN 3335
- 毒性
- LD50 orally in Rabbit: 642 mg/kg
- hs_code
- 29309070
- risk_code
- 22-36/37/38
- 化審法
- (9)-1422
- hazard_code
- Xn,Xi
- safety_code
- 36/37/39-26-36
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2Skin Sens. 1STOT SE 3
- ストレージクラス
- 11 - Combustible Solids
- 危険度評価（NFPA 704基準/消防庁データ）
- 人的[青]=1
化学と産業
薬理情報
FDA Pharmacological Classification
CYSTEAMINE HYDROCHLORIDE
Cystine Disulfide Reduction [MoA]; Cystine Depleting Agent [EPC]
MeSH Pharmacological ClassificationCompounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS.
用途と製造
Uses
Cysteamine is a natural antioxidant, precursor in taurine biosynthesis, and component of coenzyme A; Used in medical research (potent ulcerogen), as a drug (nephropathic cystinosis), and antidote (acetaminophen poisoning); [Merck Index] A radiation-protective agent that oxidizes in air to form CYSTAMINE. It can be given intravenously or orally to treat radiation sickness. The bitartrate has been used for the oral treatment of nephropathic cystinosis. [ChemIDplus] Used as an intermediate; [ECHA REACH Registrations]
Use ClassificationCosmetics -> Reducing; Antioxidant
General Manufacturing InformationEthanethiol, 2-amino-, hydrochloride (1:1): ACTIVE
応用分野
説明Cysteamine is a stable aminothiol with radioprotective activities. It reduces ionizing radiation-induced death and chromosomal damage in mice in a dose-dependent manner. Cysteamine binds rapidly and temporarily to plasma proteins upon administration and this activity is directly correlated to its radioprotective effects. In vitro, 0.1 mM cysteamine depletes 90% of free cystine from cystinotic fibroblasts. Formulations containing cysteamine have been used to treat nephropathic cystinosis and reduce glomerular deterioration in humans.
使用Cysteamine hydrochloride is used as an antioxidant and in radiation therapy.
一般的な説明Cysteamine is an aminothiol that can reduce important oxidized disulfide molecules such as cystine to yield cysteine.
調製方法
純化方法Purify the salt by recrystallisation from EtOH. It is freely soluble in H2O and should be stored in a dry atmosphere. [Mills & Bogert J Am Chem Soc 62 1177 1940.] The picrate has m 125-126o; see previous entry for free base. [Beilstein 4 IV 1570.]
上流・下流製品情報
上流原料
下流製品
補足説明
定義本品は、次の化学式で表されるアミンの塩酸塩である。
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