Hydrochloric Acid → 2-(6-Formamidopyridin-2-yl)acetic acid

HRID 1075251ノート

反応式

HRID 1075251 の反応式
[CH:1]([NH:3][C:4]1[N:9]=[C:8]([CH2:10][C:11]([O:13]CC)=[O:12])[CH:7]=[CH:6][CH:5]=1)=[O:2].[OH-].[Na+].O.Cl>C(O)C>[CH:1]([NH:3][C:4]1[N:9]=[C:8]([CH2:10][C:11]([OH:13])=[O:12])[CH:7]=[CH:6][CH:5]=1)=[O:2]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 13060164HCID 13060164、化合物

生成物 1

HCID 130601732-(6-Formamidopyridin-2-yl)acetic acid収率 65.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

To a solution of ethyl 2-(6-formamidopyridin-2-yl)acetate (4.4 g.) in ethanol (44 ml.) was added 2 N sodium hydroxide solution [solvent:water (1 part)+ethanol (4 parts] (15.9 ml.) at 18° to 20° C. over 30 minutes, and then the solution was stirred at room temperature for one hour. After 1 N hydrochloric acid (31.7 ml.) was added to the solution, the solution was concentrated under reduced pressure. The residue was extracted with hot ethyl acetate (500 ml.) and the extract was concentrated under reduced pressure. The residue was washed with ethyl acetate to give 2-(6-formamidopyridin-2-yl)acetic acid (2.5 g.), mp 125° to 126° C. (dec.).

後処理

  1. concentrationthe solution was concentrated under reduced pressure
  2. extractionThe residue was extracted with hot ethyl acetate (500 ml.)
  3. concentrationthe extract was concentrated under reduced pressure
  4. washThe residue was washed with ethyl acetate

出典と根拠

ORDレコード
ord-98804b8ebb9047d08c65ec6ccba29722
出典データセット
uspto-grants-1983_07
特許番号
US04395411

反応ノート

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