Sodium Hydroxide → 2-(6-Formamidopyridin-2-yl)-2-ethoxyiminoacetic acid

HRID 1075257ノート

反応式

HRID 1075257 の反応式
[OH-].[Na+].[CH:3]([NH:5][C:6]1[N:11]=[C:10]([C:12](=O)[C:13]([O:15]CC)=[O:14])[CH:9]=[CH:8][CH:7]=1)=[O:4].Cl.[O:20]([NH2:23])[CH2:21][CH3:22]>C(O)C>[CH:3]([NH:5][C:6]1[N:11]=[C:10]([C:12](=[N:23][O:20][CH2:21][CH3:22])[C:13]([OH:15])=[O:14])[CH:9]=[CH:8][CH:7]=1)=[O:4]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 76850O-ethylhydroxylamine hydrochlorideHCID 13060174Ethyl 2-(6-formamidopyridin-2-yl)glyoxylate

生成物 1

HCID 536595352-(6-Formamidopyridin-2-yl)-2-ethoxyiminoacetic acid収率 45.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1 N Sodium hydroxide solution (8.5 ml.) was added to a stirred solution of ethyl 2-(6-formamidopyridin-2-yl)-glyoxylate (1.9 g.) in ethanol (30 ml.) at room temperature and stirred at the same temperature for 30 minutes. After adding ethoxylamine hydrochloride (912 mg.) to the solution, the solution was stirred at room temperature for 4 hours. The resultant solution was concentrated under reduced pressure, and ethyl acetate and an aqueous solution of sodium bicarbonate were added to the residue. The aqueous layer was separated and ethyl acetate was added to the solution. The solution was adjusted to pH 1 with 10% hydrochloric acid. The ethyl acetate layer was separated, dried over magnesium sulfate and concentrated under reduced pressure. The residue was triturated with a mixture of diethyl ether and petroleum ether to give 2-(6-formamidopyridin-2-yl)-2-ethoxyiminoacetic acid (920 mg.), mp. 155° to 156° C. (dec.).

後処理

  1. stirringthe solution was stirred at room temperature for 4 hours
  2. concentrationThe resultant solution was concentrated under reduced pressure, and ethyl acetate
  3. additionan aqueous solution of sodium bicarbonate were added to the residue
  4. customThe aqueous layer was separated
  5. additionethyl acetate was added to the solution
  6. customThe ethyl acetate layer was separated
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated under reduced pressure
  9. customThe residue was triturated with a mixture of diethyl ether and petroleum ether

出典と根拠

ORDレコード
ord-e0c21d27273c4a5f9d5daa9d12c69bbf
出典データセット
uspto-grants-1983_07
特許番号
US04395411

反応ノート

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