Hydrogen Peroxide → HCID 20494718、化合物

HRID 1075300ノート

反応式

HRID 1075300 の反応式
[CH:1]([N:4]([CH:9]1[CH:14]=[C:13]([CH3:15])[CH2:12][CH2:11][CH:10]1[C:16]#[N:17])[C:5](OC)=[O:6])([CH3:3])[CH3:2].[OH-:18].[Na+].OO>C(O)C>[CH:1]([N:4]1[CH:9]2[CH:10]([CH2:11][CH2:12][C:13]([CH3:15])=[CH:14]2)[C:16](=[O:18])[NH:17][C:5]1=[O:6])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 13590129HCID 13590129、化合物

生成物 1

HCID 20494718HCID 20494718、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 100 g 2-(N-isopropyl-N-carbomethoxyamino)-4-methyl-3-cyclohexene-nitrile in 700 ml 95% ethanol are added 90 ml of concentrated aqueous sodium hydroxide. To this mixture are added dropwise within 4 hours under stirring and at an internal temperature of 40° 600 ml 40% hydrogen peroxide. Stirring is continued over night at room temperature. The reaction mixture is concentrated in vacuo and the residue treated with water and toluene. The water layer is extracted twice with toluene and the combined toluene extracts are washed with water and evaporated in vacuo to give the title compound.

後処理

  1. additionTo this mixture are added dropwise within 4 hours
  2. waitis continued over night at room temperature
  3. concentrationThe reaction mixture is concentrated in vacuo
  4. additionthe residue treated with water and toluene
  5. extractionThe water layer is extracted twice with toluene
  6. washthe combined toluene extracts are washed with water
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-00def5a16cf34ac1818825941ca8bf49
出典データセット
uspto-grants-1983_07
特許番号
US04395550

反応ノート

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